NT-proBNP

CPT Code: 83880

Order Code: C125

Synonyms: Brain natriuretic peptide; proBNP, N-terminal pro b-type natriuretic peptide

Minimum Volume: 1.0 ml

Sample Type: Serum

Tube Type: Tiger top tube

Collection:
1. Draw sample and gently invert 5 times (DO NOT SHAKE)
2. Let the blood clot for 30 minutes
3. Centrifuge sample at 1300 rcf for 30 minutes

Storage Instructions: Cleveland HeartLab recommends that the sample be stored at 4°C and shipped same day as draw.  The sample is stable for 2 days at 4°C.

Causes for Rejection: Samples will be rejected if the sample is improperly labeled

Use: NT-proBNP can be used as an aid in the diagnosis of congestive heart failure. The test is further indicated for the risk stratification of individuals with acute coronary syndrome and congestive heart failure. The test may also serve as an aid in the assessment of increased risk of cardiovascular events and mortality in individuals at risk for heart failure who have stable coronary artery disease.

Methodology: Chemiluminescence

Goal Value:
Patients < 75 years:  <125 pg/mL
Patients ≥ 75 years: <450 pg/mL

Additional Information: Higher-than-normal results suggest that an individual is in heart failure, and the level of BNP or NT-proBNP in the blood is related to the severity of heart failure. Higher levels of BNP or NT-proBNP also may be associated with a worse outlook (prognosis) for the individual. BNP and NT-proBNP levels decrease in those who have been taking drug therapies for heart failure, such as ACE inhibitors, beta blockers, and diuretics. Levels of both BNP and NT-proBNP tend to increase with age. Levels of NT-proBNP and BNP are also increased in individuals with kidney disease. While both BNP and NT-proBNP levels increase and can be measured to identify left ventricle dysfunction, they are not interchangeable and the results cannot be directly compared.