Order Code: 1172
ABN Requirement: No
Synonyms: E1
Specimen: Serum
Volume: 0.5 mL
Minimum Volume: 0.25 mL
Container: Red Top Tube (only)
Collection:
- Collect and label sample according to standard protocols.
- Gently invert tube 10 times immediately after draw. DO NOT SHAKE.
- Allow blood to clot 30 minutes.
- Centrifuge for 10 minutes.
- Aliquot serum into transfer tube.
Special Instructions: The patient’s age and gender must be specified on the requisition.
Transport: Store serum at 2°C to 8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.
Stability:
Ambient (15-25°C): 48 hours
Refrigerated (2-8°C): 7 days
Frozen (-20°C): 2 years
Causes for Rejection: Serum from SST tube; samples received at room temperature; improper labeling; samples not stored properly; samples older than stability limits
Methodology: Chromatography/Mass Spectrometry
Turn Around Time: 2 to 5 days
Reference Range:
| Age | Male pg/mL |
Female pg/mL |
| Pediatric, Pre-pubertal (1-9 years) | <10 | ≤34 |
| 10-11 years | ≤12 | ≤72 |
| 12-14 years | ≤28 | ≤75 |
| 15-17 years | ≤64 | ≤188 |
| Adult Female, Follicular Stage | na | 10-138 |
| Adult Female, Luteal Stage | na | 16-173 |
| Adult Female, Postmenopausal | na | ≤65 |
| Adult Male | ≤68 | na |
Clinical Significance: Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to estrone leading to higher concentrations. In addition, an increase in the ratio of estrone to estradiol may be useful in assessing menopause in women.
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.