HDL Cholesterol

Cleveland HeartLab H, Test

CPT Code: 83718
Order Code: C118
ABN Requirement:  No
Synonyms: Alpha- Lipoprotein Cholesterol; HDLC; HDL; High-density Lipoprotein Cholesterol
Specimen: Serum
Volume: 0.5 mL
Minimum Volume: 0.2 mL
Container: Gel-barrier tube (SST, Tiger Top)


  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.

Fasting: Not Required.

Transport: Store serum at 2°C to 8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.


Ambient (15-25°C): not acceptable
Refrigerated (2-8°C): 7 days
Frozen (-20°C): 90 days
Deep Frozen (-70°C): 24 months

Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits

Methodology: Photometric

Turn Around Time: 1 to 3 days

Relative Risk:

AgeLow Risk
Moderate Risk
High Risk
<20 years > 45N/A≤45
≥20 years, Male≥40N/A<40
≥20 years, Female≥50 N/A<50

Clinical Significance: An HDL cholesterol test can be ordered, along with other lipid tests, to determine an individual’s risk of having a heart attack, stroke or developing cardiovascular disease or peripheral vascular disease. HDL cholesterol can also be monitored regularly in individuals with one or more risk factors for developing cardiovascular disease. Testing can also be used to monitor therapy or lifestyle changes in individuals with established cardiovascular disease.

Limitations: In rare cases, elevated immunoglobulin concentrations can lead to artificially increased HDL-cholesterol results. In some patients with abnormal liver function, the HDL-cholesterol result may significantly differ from the DCM (designated comparison method) result. In very rare cases gammopathy may cause unreliable results. Extremely lipemic sera can cause spurious HDL-C results. Acetaminophen use can falsely decrease test results. Venipuncture should be performed prior to the administration of metamizole; venipuncture immediately after or during the administration of metamizole may lead of falsely low results. Elevated concentrations of free fatty acids and denatured proteins may cause falsely elevated HDL-cholesterol results.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.