Insulin-like Growth Factor 1 (IGF-1), LC/MS
CPT Code: 84305
Order Code: 16293
Synonyms: IGF1, Somatomedin-C, Insulin Like Growth Factor
ABN Requirement: No
Volume: 0.5 mL
Minimum Volume: 0.3 mL
Container: Gel-barrier tube (SST)
- Collect and label sample according to standard protocols.
- Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
- Allow blood to clot 30 minutes.
- Centrifuge for 10 minutes.
Transport: Store serum at 2°C to 8°C after collection and ship the same day per packaging instructions included with the provided shipping box.
Ambient (15-25°C): 48 hours
Refrigerated (2-8°C): 5 days
Frozen (-20°C): 28 days
Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits; specimens received in glass tube; gross hemolysis; gross lipemia; grossly icteric
Methodology: Liquid Chromatography/Mass Spectrometry (LC/MS)
Turn Around Time: 3-6 days
|Pediatric||Male (ng/mL)||Female (ng/mL)|
|Z-Scores||-2.0 – +2.0|
Clinical Significance: Insulin-like Growth Factor 1 (IGF-1 or Somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by Growth Hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.
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