Syphilis IgG with Confirmation

Cleveland HeartLab S, Test

CPT Code: 86780
Order Code: C2430
Includes: Syphilis IgG, Syphilis IgG Qualitative, Treponema pallidum IgG, Treponema pallidum IgG Qualitative, Rapid Plasma Reagin (RPR), RPR Quant Titer
ABN Requirement: No
Synonyms: Syphilis Screen; FTA-ABS; FTA-Fluorescence Treponemal Palladium Antibody IgG
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)



  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Let tube stand in a vertical position to allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.

Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.


Ambient (15-25°C): 1 day
Refrigerated (2-8°C):
7 days
Frozen (-20°C):
14 days
Deep Frozen (-70°C): 
14 days

Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits

Methodology: Multiplex

Turn Around Time: 2-3 days

Reference Range:

Syphilis IgG, QualNon-reactive
Syphilis IgG (T pallidum)Refer to report

Clinical Information: This treponemal test is the test recommended by the CDC for Syphilis screening, with confirmation by a non-treponemal test, such as RPR.

Special Information: A weakly reactive or reactive Syphilis IgG (SYPHG) result will be confirmed by RPR at an additional charge (CPT 86592). A non-reactive RPR result will have Treponema Pallidum Antibody IgG Confirmation performed at an additional charge (CPT 86780).  A reactive RPR result will have a RPR quant with titer performed at an additional charge (CPT 86593). When a Reactive specimen is found, Ohio State law requires completion of an Ohio Department of Health confidential report form.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.