Epstein-Barr Virus Antibody to Early Antigens

Cleveland Heartlab E, Test

CPT Code: 86663
Order Code: C1390
ABN Requirement: No
Synonyms: EBV EA Antibody; Epstein-Barr Virus Early Antigen Antibody IgG
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)



  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Let tube stand in a vertical position to allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.

Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.


Ambient (15-25°C): 4 days
Refrigerated (2-8°C):
7 days
Frozen (-20°C):
30 days
Deep Frozen (-70°C):
30 days

Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits; grossly hemolyzed or grossly lipemic specimens; icteric specimens; microbially contaminated specimens

Methodology: Immunoassay (IA)

Turn Around Time: 4-5 days

Reference Range:

Age Units
All Ages Negative: ≤0.90
All Ages Equivocal: 0.91-1.09
All Ages Positive: ≥1.10

Clinical Significance:
Primary infection by Epstein-Barr Virus (EBV) causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders, including tumors. IgG recognizing early antigen D typically appears within a month after clinical presentation and is transient, lasting only 3-4 months. Persistently elevated levels suggest reactivation or persistence of EBV infection.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.