ADMA/SDMA

Cleveland HeartLab A, Inflammation, New Tests, Test

One of the earliest manifestations of endothelial dysfunction is nitric oxide (NO) deficiency, which promotes atherosclerosis. ADMA (asymmetric dimethylarginine) and SDMA (symmetric dimethylarginine), its structural isomer, are metabolites of L-arginine, an amino acid that is catalyzed to L-citrulline and NO by nitric oxide synthase (NOS).

Both ADMA and SDMA have distinct pathophysiologies and manifestations. ADMA is a competitive inhibitor of NOS thereby reducing NO production and promoting endothelial dysfunction. SDMA also interferes with NO production, but does so indirectly by reducing the cellular availability of arginine. ADMA is primarily cleared through enzymatic degradation in the bloodstream and identifies subclinical cardiovascular disease. Conversely, SDMA is primarily excreted in the urine and identifies reduced renal function.
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Myeloperoxidase (MPO)

Cleveland HeartLab Inflammation, M, Test

CPT Code: 83876 Order Code: C133 ABN Requirement:  No Synonyms: MPO Specimen: EDTA Plasma Volume: 1.0 mL Minimum Volume: 0.5 mL Container:  EDTA (Lavender Top tube) Collection: Plasma: Draw and gently invert 8 to 10 times. Centrifuge immediately for 10 minutes. EDTA plasma must be separated from cells within 2 hours of collection. Pre-squeeze transfer pipet bulb and draw off approximately more »

F2-Isoprostane/Creatinine

Cleveland HeartLab F, Inflammation, Test

CPT Code: 82542/82570 Order Code: C261 Includes: F2-isoprostane, Urine Creatinine ABN Requirement:  No Synonyms:  F2 Iso; F2-IsoPs; F2αIsoprostane; IsoPF2α; F2CR Specimen: Random Urine Volume: 2.0 mL Minimum Volume:  1.5 mL Container: Urine specimen tube (Yellow Top tube without preservative) Collection: Collect urine sample according to standard protocols. Transfer aliquot from a clean urine cup into a Yellow Top tube using the vacutainer transfer more »

OxLDL

Cleveland HeartLab Inflammation, New Tests, O, Test

OxLDL measures protein damage due to the oxidative modification of the ApoB subunit on LDL cholesterol. The oxidation of LDL cholesterol is one of the first steps in the development of atherosclerosis. Briefly, LDL-C enters the artery wall where it becomes oxidized. OxLDL is then recognized by scavenger receptors on the macrophages which engulf OxLDL, resulting in foam cell formation, vascular inflammation and the initiation of atherosclerosis.
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Microalbumin/Creatinine

Cleveland HeartLab Inflammation, M, Test

CPT Code: 82043 / 82570 Order Code: Panel code: C919 Includes: Urine Albumin, Urine Creatinine, Microalbumin/Creatinine ABN Requirement: No Synonyms: Urine microalbumin; Albumin-to-Creatinine Specimen: Urine Volume: 0.5 mL Minimum Volume: 0.2 mL Container: Urine specimen tube (Yellow Top tube without preservative) Collection: Collect urine sample according to standard protocols. Transfer aliquot from a clean urine cup into a Yellow Top more »

Lp-PLA2 Activity

Cleveland HeartLab Inflammation, L, Test

CPT Code: 83698 Order Code: C570 ABN Requirement:  No Synonyms: Lipoprotein-associated Phospholipase A2; Lp-PLA2; Lp-PLA2 Activity Assay Specimen: Serum or EDTA Plasma Volume: 1.0 mL Minimum Volume: 0.5 mL Container: Serum: Gel-barrier tube (Tiger Top) preferred Plasma: EDTA (Lavender Top tube) Collection: Serum: Collect and label sample according to standard protocols. Gently invert tube 5 times immediately after draw. DO NOT more »

High-sensitivity CRP (hsCRP)

Cleveland HeartLab C, H, Inflammation, Test

CPT Code: 86141 Order Code: C121 ABN Requirement:  No Synonyms: High Sensitivity CRP; Ultra-sensitive CRP; hsCRP Specimen: Serum (preferred); EDTA Plasma Volume: 0.5 mL Minimum Volume: 0.2 mL Container: Serum: Gel-barrier tube (SST, Tiger Top) Plasma: EDTA (Lavender Top tube) Collection: Serum: Collect and label sample according to standard protocols. Gently invert tube 5 times immediately after draw. DO NOT SHAKE. more »