ADMA/SDMA

Cleveland HeartLab A, Inflammation, New Tests, Test

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CPT Code: 82542
Order Code: C301
ABN Requirement: No
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Fasting: Fasting is recommended but not required
Container: Gel-barrier tube (SST, Tiger Top)

Collection:

  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Allow blood to clot 30 minutes.
  4. Centrifuge at 1300 rcf for 10 minutes.

Transport: Store serum at 2°C to 8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab, Inc. shipping box.

Stability:

Ambient (15-25°C): 1 day
Refrigerated (2-8°C):
7 days
Frozen (-20°C):
23 days
Deep Frozen (-70°C):
23 days

Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits; hemolyzed specimens

Methodology: Tandem Mass Spectrometry (LC-MS/MS)

Turn Around Time: 4-7 days

Reference Range:

Analyte Age Low Relative Risk
ng/mL
Moderate Relative Risk
ng/mL
High Relative Risk
ng/mL
ADMA All Ages <100 100-123 >123

 

Analyte Age ng/mL
SDMA All Ages 73-135

 

Clinical Use: ADMA and SDMA may be measured in individuals with multiple risk factors for the development of cardiovascular disease.

Interpretive Information: Elevated ADMA levels are associated with significant subclinical atherosclerosis1,2 while elevated SDMA levels are associated with impaired kidney function3,4 and strongly correlate with reduced eGFR.4

References:

  1. Maas, Renke, et al. Stroke 2009; 40: 2715-2719.
  2. Iribarren, Carlos, et al. Eur J Cardio Prev Rehab. 2007; 14: 222-229.
  3. Schepers, Eva, et al. Clin J Amer Soc Nephrol. 2011; 6: 2374-2383.
  4. Kielstein, Jan T., et al. J Am Soc Nephrol. 2002; 13: 170-176.