Apolipoprotein B / Apolipoprotein A1 Ratio

Cleveland HeartLab A, Test

Order Code: Calculation automatically triggers from ordering both ApoB and ApoA1 (C511)
ABN Requirement:  No
Synonyms: ApoB/ApoA1 Ratio
Specimen: Serum or EDTA Plasma
Volume: 0.5 mL
Minimum Volume: 0.2 mL
Container: Gel-barrier tube (SST, Tiger Top) or EDTA (Lavender Top) tube



  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.


  1. Draw and gently invert 8 to 10 times.
  2. Place specimen on ice after draw.
  3. Centrifuge for 10 minutes.
  4. Pre-squeeze transfer pipet bulb and draw off approximately 2/3 of the upper plasma layer.
    Note: This ensures that the buffy coat and red cells remain undisturbed.
  5. Aliquot plasma into labeled transport tube and cap tightly. Discard original tube.
  6. Store transport tube refrigerated at 2-8°C until ready to ship.

Patient Preparation: Patient must be fasting 12 to 14 hours prior to collection.

Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.


Ambient (15-25°C): 24 hours
Refrigerated (2-8°C): 8 days
Frozen (-20°C): 2 months

Causes for Rejection: Specimens other than serum or EDTA plasma; improper labeling; samples not stored properly; samples older than stability limits

Methodology: Calculation

Turn Around Time: 1 to 3 days

Relative Risk:

Age/SexLow RiskModerate RiskHigh Risk
All Ages, Male<0.770.77-0.95>0.95
All Ages, Female<0.630.63-0.78>0.78

Clinical Significance: The ApoB/ApoA1 Ratio correlates with risk of cardiovascular disease.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.