Cardiolipin Antibodies (IgA, IgG, IgM)

Cleveland HeartLab C, Test

NEW YORK DOH APPROVED: YES
CPT Code: 86147 (x3)
Order Code: C1469
ABN Requirement: No
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)

Collection:

Serum:

  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Let tube stand in a vertical position to allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.

Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.

Stability:

Ambient (15-25°C): 4 days
Refrigerated (2-8°C):
7 days
Frozen (-20°C):
30 days
Deep Frozen (-70°C):
30 days

Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits; grossly hemolyzed or lipemic samples

Methodology: Immunoassay (IA)

Turn Around Time: 8 days

Relative Risk:

Component Age Negative Indeterminate Low to Medium Positive High Positive
Cardiolipin Antibody, IgA All Ages ≤11 APL 12-20 APL 21-80 APL >80 APL
Cardiolipin Antibody, IgG All Ages ≤14 GPL 15-20 GPL 21-80 GPL >80 GPL
Cardiolipin Antibody, IgM All Ages ≤12 MPL 13-20 MPL 21-80 MPL >80 MPL

Intended Use: Used to help determine the cause of an unexplained blood clot (thrombotic episode) or recurrent miscarriages.

Clinical Significance: Cardiolipin antibodies are seen in a subgroup of patients with autoimmune disorders, particularly system lupus erythematosus, who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct, and/or recurrent spontaneous abortion. Elevations of cardiolipin antibodies associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren’s syndrome.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.