Fibrinogen Mass

Cleveland Heartlab Coagulation/Platelet Function, F, Test

CPT Code: 85385
Order Code: C334
ABN Requirement:  No
Synonyms: Factor I;  Fibrinogen Antigen
Specimen: Plasma collected in NaCitrate anticoagulant
Volume: 0.5 mL
Minimum Volume: 0.2 mL
Container: Sodium Citrate (Light Blue Top tube)


  1. Collect and label sample according to standard protocols. It is important to fill the tube to the fill-line.
  2. Gently invert tube 3-4 times immediately after draw. DO NOT SHAKE.
  3. Centrifuge for 10 minutes.
  4. IMMEDIATELY aliquot plasma into transfer tube, label the tube with patient’s full name, date of birth and specimen type (for example: NaCit plasma) and refrigerate.

Transport: Store plasma at 2°C to 8°C after collection and ship the same day of collection per packaging instructions included with the provided shipping box.


Ambient (15-25°C): not acceptable
Refrigerated (2-8°C): 48 hours
Frozen (-20°C): >48 hours

Causes for Rejection: Specimens that are collected in anticoagulants other than sodium citrate; improper labeling; samples not stored properly; samples older than stability limits

Methodology: Immunoturbidimetric Assay

Turn Around Time: 1 to 5 days

Reference Range:

Age mg/dL
All Ages 196-441


Priority Value:

Age Priority 2 Value (mg/dL)
All Ages <100

Clinical Significance: Low levels of fibrinogen are associated with bleeding most commonly secondary to liver disease or Disseminated Intravascular Coagulation (DIC). Fibrinogen is an acute phase reactant and thus elevated levels may be associated with inflammation. Increased concentrations are also associated with increased risk of atherosclerosis.

Limitations: Grossly lipemic samples and samples that have very high triglycerides should be avoided. Clotted samples should be avoided.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.