Order Code: C2371
Includes: Thyroglobulin and Thyroglobulin Antibody Screen
ABN Requirement: No
Volume: 1.0 mL
Minimum Volume: 0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)
- Collect and label sample according to standard protocols.
- Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
- Let tube stand in a vertical position to allow blood to clot 30 minutes.
- Centrifuge at 1300 rcf for 10 minutes at room temperature.
Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab, Inc. shipping box.
Ambient (15-25°C): 24 hours
Refrigerated (2-8°C): 7 days
Frozen (-20°C): 60 days
Deep Frozen (-70°C): 60 days
Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits
Methodology: Chemiluminescence Immunoassay (CLIA), Chemiluminescent Microparticle Immunoassay (CMIA)
Turn Around Time: 2-5 days
|Thyroglobulin Antibody Screen||All Ages||<14.4|
Clinical Significance: Serum thyroglobulin levels correlate well with the volume of differentiated thyroid tissue, hence are increased in thyrotoxicosis, thyroiditis, iodine deficiency, benign thyroid adenomas, and thyroid cancer. Thus, although it is unsuitable as a screening tool for differentiated thyroid cancer (DTC), it is a highly sensitive marker for the detection of residual or recurrent disease after a total thyroidectomy and successful radioiodine remnant ablation. Presence of thyroglobulin autoantibodies interfere with in the assay and thyroglobulin levels are underestimated in the antibody positive patients.