Growth Hormone (GH)

Cleveland Heartlab G, Test


CPT Code: 83003
Order Code: C1409
ABN Requirement: No
Synonyms: Human Growth Hormone, hGH, HGH, GH
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)


  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.

Patient Preparation:  Random Growth Hormone collection should be performed on fasting patients who have rested for at least 30 minutes before collection.

Transport: Store serum at 2°C to 8°C after collection and ship the same day per packaging instructions included with the provided shipping box.


Ambient (15-25°C): 7 days
Refrigerated (2-8°C): 14 days
Frozen (-20°C): 28 days

Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits

Methodology: Immunoassay (IA)

Turn Around Time: 2 to 3 days

Reference Range:

Age ng/mL
Children (<20 years) ≤10.1
Adults ≤7.1

Because of a pulsatile secretion pattern, random (unstimulated) growth hormone (GH) levels are frequently undetectable in normal children and adults and are not reliable for diagnosing GH deficiency. Regarding suppression tests, failure to suppress GH is diagnostic of acromegaly. Typical GH response in healthy subjects: Using the glucose tolerance (GH Suppression) test, acromegaly is ruled out if the patient’s GH level is <1.0 ng/mL at any point in the timed sequence. [Katznelson L, Laws Jr ER, Melmed S, et al. Acromegaly: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2014; 99: 3933-3951]. Using GH stimulation testing, the following results at any point in the timed sequence makes GH deficiency unlikely: Adults (> or = 20 Years): Insulin Hypoglycemia > or = 5.1 ng/mL Arginine/GHRH > or = 4.1 ng/mL Glucagon > or = 3.0 ng/mL Children (< 20 Years): All Stimulation Tests > or = 10.0 ng/mL

Clinical Significance: Measurement of GH is primarily of interest in the diagnosis and treatment of various forms of inappropriate growth hormone secretion. Growth hormone measurements in children are used in the evaluation of short stature and help differentiate low GH production from other sources of growth failure. Stimulation and suppression tests are often more meaningful than random measurements.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.