Levetiracetam (Keppra)

Cleveland Heartlab L, Test

NEW YORK DOH APPROVED: YES

CPT Code: 80177
Order Code: 15142
ABN Requirement: No
Alternative Name(s): Keppra
Specimen
:
    Preferred: Serum
Alternative:
EDTA Plasma
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Container:
Preferred: Red Top Tube (no gel barrier)
Alternative: Lavender Top Tube (EDTA)

Collection:

Serum:

  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. Do not shake.
  3. Allow blood to clot 30 minutes.
  4. Centrifuge specimen for 10 minutes.
  5. Aliquot serum into transport tube labeled as “Red Top Serum” and cap tightly. Discard original tube.

EDTA Plasma:

  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 10 times immediately after draw. Do not shake.
  3. Centrifuge specimen for 10 minutes.
  4. Aliquot plasma into transport tube labeled as “EDTA Plasma” and cap tightly. Discard original tube.

Collection Instructions: Collect in red-top tube (no gel). Avoid use of serum separator tube (SST), as the drug may be adsorbed into the gel.

Patient Preparation: Collect at trough level (i.e. immediately prior to next dose).

Transport: Store serum or EDTA plasma at 2°C to 8°C after collection and ship the same day per packaging instructions included with the provided shipping box.

Stability:

Ambient (15-25°C): 14 days
Refrigerated (2-8°C):
28 days
Frozen (-20°C):
60 days

Causes for Rejection: Specimens other than serum or EDTA plasma; improper labeling; samples not stored properly; samples older than stability limits; serum separator tube (SST)

Methodology: Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Turn Around Time:  3 to 4 days

Reference Range:

Age Reference Range (mcg/mL)
All 12.0-46.0

Toxic level is not well established. Interpretation should include a clinical evaluation.

Priority Values:

All Ages Priority 2 Value (mcg/mL)
Peak >70.0
Trough >37.0

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Clinical Significance: Levetiracetam is an anticonvulsant used as adjunct therapy to treat adult partial seizures. As multiple anticonvulsants are administered, it is important to monitor its level to (1) optimize therapy, (2) assure compliance, and (3) to avoid toxicity.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.