Tissue Transglutaminase (tTG) Antibody (IgG)

Cleveland Heartlab T, Test

CPT Code: 83516
Order Code: C1134
ABN Requirement: No
Synonyms: Transglutaminase, Tissue Antibody IgG, tTg IgG
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)



  1. Collect and label sample according to standard protocols.
  2. Gently invert tube 5 times immediately after draw. DO NOT SHAKE.
  3. Let tube stand in a vertical position to allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.

Transport: Store serum at 2-8°C after collection and ship the same day per packaging instructions provided with the Cleveland HeartLab shipping box.


Ambient (15-25°C): 4 days
Refrigerated (2-8°C):
7 days
Frozen (-20°C):
30 days
Deep Frozen (-70°C):
30 days

Causes for Rejection: Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits; grossly hemolyzed or lipemic samples

Methodology: Immunoassay (IA)

Turn Around Time: 5 days

Reference Range:

Age No Ab Detected Ab Detected
All Ages <6 U/mL ≥6 U/mL


Intended Use: To aid in the diagnosis of gluten-sensitive enteropathies in patients who are IgA-deficient.

Clinical Significance: Tissue Transglutaminase Antibody (IgG) is useful in the diagnosis of enteropathies, such as Celiac Sprue Disease, and an associated skin condition, dermatitis herpetiformis.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.